Endocrine Abstracts

Insulin has been shown to participate in the long-term regulation of satiety, and it is emerging as a peripheral modulator of the activity of the neuroendocrine reproductive axis as well. Following the observation that mice lacking the expression of brain insulin receptors exhibit central hypogonadism and infertility, we could show that peripheral insulin can stimulate LH secretion in rodents. This effect is likely mediated at the level of the hypothalamus, as suggested by the...